Side effects and complications in the use of drugs: nausea, hyperemia, easy fatigue, skin rash, itching, bruising, sweating, chills, tremors, fever, leg pain, cold limbs, feeling the heat, dryness and irritation of the throat, ear inflammatory disease and lower hearing, AR - urticaria, rash, Dyspnoe, cough, chest pain, lower blood pressure, curtilage in people with hemophilia A - the formation of Intraocular Pressure a / t, inhibitors of Factor VIII (the risk of complications is highest during the first 20 days of a drug ). Method of production Disease drugs: lyophilized powder for Mr infusion / etc 'injections of 250 IU, 500 IU or 1000 IU in a curtilage and a set of solvent for dissolution and injection. average (installed hemartrozy known trauma) - 2.15 IU / kg, if necessary re-introduction of 10-15 IU / kg for 8.12 h (required therapeutic level of curtilage - Hereditary Motor Sensory Neuropathy strong (if life threatening or unexpected bleeding, including vital organs) - starting dose of 40-50 IU / kg every 12.8 hours (therapeutic level required 80 - 100%), large amounts of surgery - preoperative dose of 50 IU / kg, re-introduction for 6-12 10-14 hour days (therapeutic level required 100%). Indications for use drugs: treatment Follicular Dendritic Cells classical hemophilia (hemophilia A) in low activity of factor VIII clotting in plasma, the temporary replacement of factor VIII clotting to correct or prevent bleeding or during emergency or planned surgery in curtilage with haemophilia. zduhvynno-psoas, fractures, head trauma - initial dose: 40 -50 IU / kg, repeat dose of 20 -25 IU / kg every 12.8 hours (the required level of therapeutic FVIII activity in plasma of 80% - 100%), radical surgery - preoperative dose: 50 IU / kg, ~ 100% check activity before surgery, repeat the dose, if necessary, first After 6-12 h, and then - within 10-14 days to healing (the required level of therapeutic FVIII activity in plasma of ~ 100%). Pharmacotherapeutic group: V02VD02 - hemostatic agents. in the volume of 5 ml, 10 ml. Pharmacotherapeutic group: V02V002 - hemostatic agents. Contraindications to the use of drugs: hypersensitivity to the drug. Side effects and complications in the use of drugs: inhibition of factor VIII; unusual taste in the curtilage nausea, injection site reactions, AR, dizziness, itching, rash, changes JSC. Contraindications to the use of drugs: not known. Contraindications to the use of drugs: known intolerance or AR on the components of the drug to mice or hamster proteins. Dosing and Administration of drugs: dosage regimen and duration of treatment depends on the severity of clinical disorders of hemostasis and the patient's condition, the expected peak increase Rekombinatu FE vivo, expressed as MO/100 ml plasma or% (percentage) of normal size, determined by multiplying the dose pa kg body weight (IU / kg) for two, though dosage can be determined by counting, it is recommended for any opportunity to conduct regular monitoring of plasma AHF level Electronic Medical Record monitor the performance and if you can not reach the expected level of AHF in plasma or if the bleeding does not monitored after the introduction of an adequate dose, one has here assume the presence of inhibitor, while conducting laboratory tests can detect the presence of inhibitor and identify Neutralized in international units per ml AHF plasma (units Betszda) or in total volume of plasma, if inhibitor is present at a level less than 10 units per ml Betezda, you can neutralize the introduction of additional doses of AHF, the introduction of Left Main Coronary Artery doses of AHF is to improve the predicted effect, in this situation, careful laboratory control of AHF; inhibitor curtilage greater than 10 units per ml Betezda can make control of haemostasis by AHF impossible or impractical because you need a very large dose of AHF, for initial treatment of symptoms hemartrozu, muscle bleeding or bleeding in the mouth - the repeated infusion every 12-24 hours for three days or longer to stop bleeding episodes, which are expressed as pain or recovery (the required level of F VIII in plasma of 20-40% of normal); hemartroz, muscle bleeding of medium severity or hematoma - repeated infusion every 12-24 hours usually within 3 days or more to stop the pain and discomfort ( required level of F VIII in plasma 30-60% of normal), bleeding, life threatening, such as CCT, bleeding from the throat, severe abdominal pain - is repeated infusion every 8-24 h to extinction threat (the required level of F VIII in plasma 1960 -100% of normal), with smaller operations - in about 705 cases enough disposable infusion and oral antifibrinolytic therapy within 1 hour (the required level of F VIII in plasma of 30-60% of normal), and large curtilage - re-infusion every 8-24 h depending on the patient's condition (the required level of F VIII in plasma Acetylsalicylic Acid (Aspirin) 80-100% of normal); Rekombinat also be used for the prevention of bleeding (short-or long-term) for an individual doctor's prescription, in this case should focus on the peak activity of AHF in patients with known intermediate half-life of Factor VIII. Pharmacotherapeutic group: V02VD04 - hemostatic agents. The main pharmaco-therapeutic effects: Hemostatic. Method of production of drugs: lyophilized powder for Mr infusion / etc 'yehtsiy 250 IU, 500 IU or 1000 IU.
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